Hendra Virus was first reported in a suburb of Hendra, Brisbane in 1994. This outbreak of the disease resulted in death of 13 horses and a trainer. Since this outbreak, there were more incidents reported from the north of Queensland in Cairns to the New South Wales border at Murwillimbah. Because of a high number of incidents reported since the outbreak there is the need for further research. The Queensland Government Department of Agriculture, Fisheries and Forestry stated that there is a pressing need for current research on the spatial and temporal occurrences of the virus infections (in Research updates of Hendra Virus, 2012 – Queensland Government). This paper presents an overview of the research and the preliminary results of the relationship between the Hendra disease outbreaks and the roosting sites of the flying-foxes in the South-east Queensland region, Australia. The results show a strong relationship (92%) between the temporary and seasonal sites rather than the permanent continuous roosting sites and the outbreaks. This finding suggests the need for detailed cluster analysis and regression models.